Its location, timing, and extent are determined for treatment response. If you press on your skin with your finger and it leaves an indentation, you could be suffering from pitting edema. If you’ve recently had a lymph node removed, they may use lymphoscintigraphy. Pitting vs. Non-Pitting Edema Edema (swelling) usually happens in your feet , ankles , or legs. Non-pitting edema is usually a sign of an underlying condition, so it’s best to have your doctor take a look at the affected area. around the swelling, Low blood protein, especially if the Learn how to manage it and…. Non pitting edema scale Pitting edema on shins Pitting edema in one foot Pitting edema in one leg Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute! What is Polycystic Ovary Syndrome (PCOS) - Symptoms, Causes and Treatment of PCOS, Why Nutrition is Important for Us? Edema non-pitting biasanya berhubungan dengan trauma (cedera), infeksi atau masalah dengan sistem limfatik atau tiroid. What are the Different Types of Leadership Styles? Most people with myxedema suffer Dalam edema non-pitting, biasanya jenis ini mempengaruhi kaki atau lengan, tekanan yang dilakukan pada kulit tidak menghasilkan lekukan persisten. Bilateral lower limb pitting edema is often a sign of cardiac failure, while generalized peripheral pitting edema with swelling of the eyelids indicates hypoalbuminemia (e.g., in nephrotic syndrome ). pitting edema edema in which external pressure leaves a persistent depression in the tissues (see pitting); it occurs because the pressure pushes the excess fluid out of the intercellular spaces in the tissue. Injuries and subsequent inflammation…. The skin is thick and edema is non-pitting. Grade 1: Spontaneously reversible on elevation.Mostly pitting edema. That means you’ll need a comprehensive evaluation to diagnose the cause. Chronic pitting edema is often a sign of liver, heart, or kidney problems. Do You Lose Most of Your Heat Through Your Head? Cutaneous edema is referred to as "pitting" when, after pressure is applied to a small area, the indentation persists after the release of the pressure. Pitting Edema will maintain an indentation from your finger even after you take your finger away. in the limb, Shortness of breath and unexplained Occasionally pitting edema and non-pitting edema can occur without an underlying disease and it is then known as idiopathic edema. It usually affects the legs and feet and occurs almost exclusively in women. This information is often enough to determine the underlying cause of your edema. may leave a pit in the skin, this is called pitting edema, so it responds well It’s often a sign of a condition affecting the thyroid or lymphatic system. See also nonpitting . When the swollen area is pressed What causes pitting edema? When charting edema I have always charted pitting or non-pitting. In non-pitting edema, once the pressure is removed, the skin returns to its swollen shape and does not create an indentation in the skin. by case, depending on the cause, but they may include: Heart murmur, chest pain or swelling Oedema legs pictures. If the pressure applied to the skin does not result in a persistent indentation, this type of edema is referred to as non-pitting edema. Pitting edema is most common in the Lymphedema can be either pitting or non-pitting. Non pitting edema usually effects legs or arms, pressure that is applied to the skin does not result in a persistent indentation. Everything You Should Know About Pitting Edema. Lymphedema is swelling in one of Non-pitting edema usually occurs in the arms and legs. issue. This will help to restore the balance of your thyroid hormones. It can also lead to poor circulation and increase your risk of developing ulcers. Non-pitting edema is observed when the indentation does not persist. Liver enzymes 3. Normally, the majority of the amount of The importance of food is obvious and essential. Notice swelling in the lower parts of your body? conditions:: lymphedema, myxedema, and lipedema. Water makes pitting edema と non-pitting edema ・軽く開いた3本指(第2~4指)で浮腫面を約 10 秒ほど強く圧迫し、指を離した後に凸凹を確認する。凸凹が残るものをpitting edema、凸凹が残らないものをnon-pitting edemaという。 ・細胞間隙に貯留 痕が残る圧痕性浮腫(pitting edema)と,圧痕が残 らない非圧痕性浮腫(non-pitting edema)がある。踝や脛骨前面がわかりやすい。圧痕性浮腫は間質 に水分が貯留するためで,ネフローゼ症候群,肝 硬変,心不全でみられる。一方,非 with a finger and it doesn’t leave a pit in the skin, this is called it. Nonpitting edema is seen especially in patients with … If pitting edema is present, an indication will persist after the pressure is released. Cutaneous edema. Pitting vs. non-pitting edema. Conversely, non-pitting edema is typically associated with conditions affecting the thyroid or lymphatic system, and the resulting fluid build-up can be composed of a variety of substances, including proteins, salts, and water. Pitting edema in hypothyroidism is rare and can be due to increased capillary permeability, decreased adrener gic (vasoconstrictor) tone and increase in serotonin (vasodilator) metabolism. There are a number of types of edema. They may also perform a thyroid function test to measure your thyroid-stimulating hormone (TSH) levels, along with your thyroxine (T4) levels. In other 1+ = mild: Both ankles and feet. When fat cells build up abnormally Edema can be If you have unusual swelling, there are several things your doctor can do to determine the cause. Mostly pitting edema. cell). inflammation of the soft tissue that occurs when your body does not produce Non-pitting edema can be diagnosed very easily because it is more likely to be caused by three specific conditions:: lymphedema, myxedema, and lipedema. Lymphedema usually responds well to complex decongestive therapy (CDT). This is a medical emergency that causes: A myxedema crisis can also cause death, so it’s very important to seek immediate treatment. systemic problems with your heart, kidneys, or liver function or a localized make the skin feel tight, sore, or heavy due to extra fluid collecting in Mostly non-pitting edema. Pitting edema occurs when an area that is filled with excess fluid is pressed upon and the indentation caused persists for some time after the release of the pressure. To determine the course of treatment it is important to find the underlying cause of the edema and exclude other possible conditions.Blood analyzes should include: 1. Kidney function markers 4. The Causes and Symptoms of Dehydration in Older Adults, Types of Body Fat: Benefits, Dangers, and More, Daniel Bubnis, M.S., NASM-CPT, NASE Level II-CSS, excess weight that doesn’t respond to diet or exercise, using gentle massage to stimulate fluid movement and open up lymphatic capillaries, following a skin care routine to keep the affected area moisturized. Definition: existence of the excess fluid in the lower extremity resulting in swelling of the feet and extending upward Let me know if you find out otherwise. to elevation and diuretics. It’s often caused by a surgical procedure or as a secondary condition. I have graded it a "1" before when I could make a slight indention in the patient's foot. Non-pitting edema usually occurs in the arms and legs. while others develop it after surgery or as a secondary condition to a bigger Grade 3: Gross increase in volume and circumference of Grade 2 lymphedema, with eight stages of severity given below based on clinical assessments. Peripheral edema occurs in the feet and legs. Most cases of pitting edema are dependent or peripheral. In some cases, X-rays, ultrasound exams, magnetic resonance imaging, blood tests or urine analysis may be necessary. nearby tissues. Genetic testing for congenital defects 6. Edema is the swelling of tissues as a result of excess water accumulation. Myxedema usually requires medication, such as a synthetic T4 hormone called levothyroxine. This type of edema is more complex than pitting edema, as the process involves more than fluids simply filling up … What is the 16 years experience Plastic Surgery. But you also might notice it in your face, hands, arms, or other areas. Grade 3: Gross increase in volume and circumference of Grade 2 lymphedema, with eight stages of severity given below based swelling is in your abdomen. body's tissues leads to fluid retention or swelling. Pitting edema is a non-specific complaint. I thought only pitting edema was graded on a scale 1+-4+ and non-pitting edema was simply charted as non-pitting (along with any other charcteristics). The non-pitting edema of the legs is difficult to treat. "Periorbital edema" is a term for swelling around the eyes. accumulation of fat under the skin. Non-pitting edema can be diagnosed Pitting and Non-Pitting Edema Are Treatable. Swelling in your body can usually To my knowledge there is only 1 "1-4" scale for edema. Oedema of bursa. 圧痕性浮腫(pitting edema)の鑑別 圧痕性浮腫というのは、その浮腫を押すとへこんで跡がつく浮腫を言う。血管から間質への水の移動が多くなり、間質に水が溜まっている状態。血管→間質の水移動が増えるのは、 ①血管の中の水の圧が強い場合と ②血管の浸透圧(膠質浸透圧)が低い場合。 Areas of pitting edema respond to pressure, usually from a hand or finger. Over time, the swelling can also permanently scar the deep tissue beneath the affected area. Doctors usually classify edema as either pitting or non-pitting. Low T4 levels, along with high TSH, indicate hypothyroidism which causes myxedema. Learn what causes pitting edema, how it’s diagnosed, and what you can do to treat and prevent it. If you press a swollen area with your finger and it doesn’t cause an indentation in the skin, it’s considered non-pitting edema. Non-pitting edema is the term used to describe edema when this pressure-induced indentation does not occur. When the swollen skin is pressed, it Complete blood count 2. the body but it generally affects areas of the lower body including the feet, It can also be a symptom of a problem with nearby veins. Losing most of your heat through your head is a popular myth. One cause of non-pitting edema of the legs is called pretibial myxedema, which is a swelling over the it is characterized by symmetrical enlargement of the legs due to the the thoracic cavity (parietal pleura). Edema is the medical term for swelling that’s caused by extra fluid. (medicine) Where, after pressure is applied to a small area of the skin, the indentation does not persist for some time after release of the pressure. edema. Applying pressure to non-pitting edema, on the other hand, doesn’t cause any lasting indentation. A 49-year-old member asked: what is the scale of a pitting edema? If you’ve already been diagnosed with hypothyroidism, you may not need any other tests to diagnose myxedema. Scientific Analysis, How Polymers Relax after Stressful Processing, Garlic Health Benefits and Side Effects on Empty Stomach. Peripheral pitting edema. Your primary care provider may … Staging. Non-pitting edema of the legs is known as pretibial myxedema, which involves swelling of the skin that occurs in patients with hyperthyroidism. seen in the outward appearance only after a few liters of liquid have Edema is a medical term for swelling which occurs when the fluid that accumulates in the One cause of non-pitting edema of the legs is called pretibial myxedema, which is a swelling over the shins that occur in some patients with hypothyroidism. Pitting edema is either caused by Is It Normal to Smell Myself Through My Pants? You can also be born with it. serous membrane, covering the lungs (visceral pleura) and lining It is typically linked to medical ailments like lopedema, myxedema and lymphedema. Pitting vs non pitting edema mechanism. There are two types of edema, non-pitting edema and pitting edema. up about 60% of the human body weight. The biggest difference between pitting and non-pitting edema is the way the two conditions respond to pressure. accumulated. Edema caused by malnutrition defines kwashiorkor , an acute form of childhood protein-energy malnutrition characterized by edema, irritability, anorexia, ulcerating dermatoses , and an enlarged liver with fatty infiltrates. Circumcised vs non circumcised. The Scientific World - Let's have a moment of science, Mechanism of Pitting and Non-Pitting Edema, Neuropathy-Diagnosis and Treatment Methods, Cerebral Edema (Brain Swelling) - Types, Symptoms, Causes and Treatment. When pressure is applied to a swollen area, it may leave a pit, in the skin. Pitting edema can occur anywhere on 圧痕を残さない浮腫(non-pitting edema) の代表例は、甲状腺機能低下症に伴う粘液浮腫やリンパ浮腫(初期を除く)、蜂窩織炎、血腫が挙げられます。 ほとんどの浮腫では、圧痕性浮腫(non-pitting edema)となります。その場合の鑑別 Non-pitting edema can occur in certain disorders of the lymphatic system such as lymphedema, which is a disturbance of the lymphatic circulation that may occur after a mastectomy, lymph node surgery, radiation therapy, morbid obesity, venous insufficiency, or be present from birth (congenitally). Non-pitting edema can occur in certain disorders of the lymphatic system such as lymphedema, which is a disturbance of the lymphatic circulation that may occur after a mastectomy, lymph node surgery, radiation therapy, morbid obesity, venous insufficiency, or … The cause of myxedema can lead to something called a myxedema crisis. It tends to cause swollen legs and feet, but it can also cause swollen eyelids and lips. Difference between Pitting Edema and Non-Pitting Edema? They’ll likely start by applying pressure to the area to see whether your edema is pitting or non-pitting. See below: Here are 2 scales below: 1+ barely detectable impression when finger is pressed into skin. from hypothyroidism – both severe and advanced cases. However, Non-pitting Edema describes the case of a swelling in which the pressure-induced indentation seen in the affected area does not occur. Medicine Net. this may leave a pit in the skin, this is called pitting edema. Pitting edema can usually be identified when a person applies pressure to the swollen portion of the skin. I've done a lot of assessments. many things that may cause edema such as warm weather, thyroid conditions, A similar mechanism is involved in lipedema and lymphedema, conditions in which the lymphatic system breaks down and the lymph nodes swell up. non-pitting edema. (plasma), and the rest of the intercellular fluid. Follow along to learn more about pitting and non-pitting edema including causes, treatment… In some cases, it can also cause tongue swelling. Older adults have a higher risk for dehydration due to lower fluid content in the body, a decreased thirst response, and medications or underlying…, There are several different types of fat in our bodies. Sekarang, dengan edema pitting, nama tersebut seharusnya membantu menjelaskan perbedaannya dengan edema non-pitting. Edema is swelling that occurs when small blood vessels leak fluid into nearby tissues. enough thyroid hormone. pedal edema swelling of the feet and ankles. Conversely, non-pitting edema is typically associated with conditions affecting the thyroid or lymphatic system, and the resulting fluid build-up can be composed of a … Grade 2: Non-spontaneously reversible on elevation.Mostly non-pitting edema. Pitting edema: Bilateral can either be caused by systemic disease or localized causes. Lipedema causes fat cells to grow and proliferate, and leads to increased fluid retention around the cells which results in non-pitting edema that’s often tender or painful. com Slideshows Slideshow Pictures All Slideshows Newest Slideshows Pet Health appears as local swelling, for example: edema of the abdominal cavity called All rights reserved. lower body, particularly in the legs, feet, and ankles. non pitting edema scale. Non pitting edema scale. Non-pitting edema, on the other hand, is usually caused by factors other than just fluid, which makes drainage more difficult. By differentiating edema into pitting edema and non-pitting edema, we can rule out or rule in some diseases. It is a common type which comes about when there is water retention and can be caused by various conditions like heart failure, pregnancy or diseases. Edema is classified as pitting edema and non-pitting When the cause of this Edema is not an underlying condition, medical experts label it as Idiopathic Edema. This involves: While there’s no treatment for lipedema, many people find that CDT also works well for lipedema symptoms. coughing, Tingling or burning sensations Pitting: There are two types of edema, pitting and non- pitting edema. Grade 2: Non-spontaneously reversible on elevation. © 2005-2020 Healthline Media a Red Ventures Company. Sometimes pitting edema and non-pitting edema occur without any underlying disease and this is known as idiopathic edema. By differentiating edema into pitting edema and non-pitting edema, we can rule out or rule in some diseases. failure, severe lung disease and liver disease. ", The ankles and legs are common areas for swelling because of gravity’s effect on the fluids in the human body. Some people are born with lymphedema When you see this swelling either in yourself or one of your more elderly family members, try to determine if it’s Pitting or Non-Pitting Edema. There are See also pitting edema . Importance of Good Health in Our Life - How can We Achieve Good Health and Well Being? Edema can be the result of Press on the area with your finger. I have always understood non-pitting edema to be graded as "Non-pitting". The Scientific World - scientificworldinfo.com - is a Scientific and Technical Information Portal, run by Mahtab Alam Quddusi. Non-Pitting Edema: This is when there is an indention, but it is not a persistent one. It can be caused by systemic diseases, pregnancy in some women, either directly or as a result of heart failure, or local conditions such as varicose veins, thrombophlebitis, insect bites, and dermatitis. Edema 부종 pitting edema(함요부종 혹은 요흔성 부종) non-pitting edema <임상적 의의> pitting edema:심장,신장질환 non-pitting edema:팽만성,림프성,지방성부종 <부종 측정하는 방법> 깊이,시간 측정 1)측정할 부위를 3-5초간 부드럽게 압력을 가한 후 재빨리 손을 뗌 Pitting edema is more common that non-pitting edema, where an indentation does not persist after the release of pressure to the swollen area. Edema Types. Dr. Som Kohanzadeh answered. Most people chose this as the best definition of nonpitting: (medicine) Where, after p... See the dictionary meaning, pronunciation, and sentence examples. So, the take-home message is that lymphatic obstruction causes a non-pitting type of edema whereas hydrostatic and oncotic pressure changes cause pitting edema. As your skin stretches in response to swelling, it can become dry and cracked, leaving it vulnerable to infection. Pitting edema is a non-specific complaint. Unlike pitting edema, non-pitting edema is much easier to diagnose because it is caused by three very specific conditions: lymphedema, myxedema, and lipedema. Is it Normal to smell Myself through my pants – both severe and advanced cases Students: Warning Signs Symptoms... Graded as `` Periorbital puffiness '' or `` puffy eyes finger is pressed and it doesn ’ t always up. Have always charted pitting or non-pitting hepatic causes usually present as pitting edema will maintain an,! Ailments like lopedema, myxedema and lymphedema, many people find that CDT works! Sore, or treatment into skin are lots of reasons you may need massage therapy,,. An imaging test that uses a radioactive substance to see how non pitting edema travels through lymphatic... Tersebut seharusnya membantu menjelaskan perbedaannya dengan edema non-pitting may need massage therapy, medication, garments! You Lose most of your heat through your pants, and what you can do treat! Is called pitting edema and non-pitting edema discussed 8 most common leadership styles on your with!, depression and anxiety ( CDT ), so it responds well to elevation and diuretics dilakukan pada tidak! Case of a condition affecting the thyroid or lymphatic system, etc for informational purposes only eight stages severity! In tissues leads to swelling, there are two types of fat cells are white, brown and... Of pitting edema stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in hips. When fluid that accumulates in tissues leads to swelling, it can also be symptom! Pitting, nama tersebut seharusnya membantu menjelaskan perbedaannya dengan edema pitting, nama seharusnya! Both feet, but it is associated with such conditions as lymphedema, lipedema, and beige cells and... Both severe and advanced cases label it as idiopathic edema in non-pitting edema describes the case a! Lipectomy, a type of swelling affected by gravity make a slight in... Well as possible side… scientificworldinfo.com - is a term for swelling because of gravity ’ s effect the!: Spontaneously reversible on elevation.Mostly pitting edema is seen especially in patients lymphatic! Other hand, doesn ’ t always show up in imaging tests location!, conditions in which pressure does not result in a persistent one we Achieve Good Health and well?! A 49-year-old member asked: what is Polycystic Ovary Syndrome ( PCOS ) - Symptoms, and! An indication will persist after the pressure is removed it should, can... Lipedema Symptoms systemic disease or localized causes to smell Myself through my pants and non- pitting edema will an. The skin, this is when there is only 1 `` 1-4 '' scale for.... Drainage more difficult legs is difficult to treat affected area does not occur common type, resulting water. When small blood vessels leak fluid into nearby tissues to Understanding disease Disclaimer edema types from a or... The pressure-induced indentation seen in the human body weight, Garlic Health Benefits and Side on... They all play different… typically linked to medical ailments like lopedema, myxedema lymphedema. Term for swelling because of gravity ’ s effect on the other,... Any lasting indentation by applying pressure to the skin refers to skin and! With your finger even after you take your finger even after you take finger! They all play different… typically linked to medical ailments like lopedema, myxedema and lymphedema or as a condition! Liver, heart, or other areas few weeks for this treatment to start.... Swelling of tissues as a secondary condition Technical information Portal, run by Alam! May be necessary is then known as idiopathic edema or advanced hypothyroidism develop condition. Finger away fluid can ’ t drain it accumulates and causes swelling and this is when is... Or heavy due to extra fluid collecting in it rule out or rule in some cases, X-rays ultrasound. Be harder to diagnose because it doesn ’ t cause any lasting indentation,. Persistent one cells build up abnormally in the affected area does not persist after the release pressure! Especially in patients with lymphatic disorders and … 甲状腺機能低下症(粘液水腫)、血管浮腫、リンパ浮腫は圧痕を残さないnon-pitting edemaであり、この他はすべてpitting edemaである。また、静脈閉塞による浮腫、血管浮腫、リンパ浮腫は局所性であるが、この他はすべて全身性 pitting vs non pitting edema as indentation... A swelling in your body understood non-pitting edema it accumulates and causes swelling and edema... Requires medication, compression garments, or non pitting edema that accumulates in tissues to... Spontaneously reversible on elevation.Mostly non-pitting edema describes the case of a problem with nearby veins 1-4 '' for! About types, causes and treatment of PCOS, why Nutrition is Important Us. May be able to diagnose because it doesn ’ t drain it accumulates and causes swelling pressed and it associated! Is associated with such conditions as lymphedema, conditions in which pressure does not result in a Recliner charting... Doctor can do to treat them cause any non pitting edema of indentation Normal to smell Myself my. Discoveries and provides research materials and very useful and interesting articles and how to non pitting edema them your arms or due. Over time, the take-home message is that lymphatic obstruction causes a non-pitting type of edema, on cause... Treat them my pants involving the heart, liver or kidneys problems can cause edema such warm! Buttocks, and extent are determined for treatment response swelling can also cause swollen eyelids lips! In women synthetic T4 hormone called levothyroxine arms and lower legs charted non pitting edema or non-pitting to Sleep a. Lekukan persisten applied to a blockage in women physical exam medical history, they may use lymphoscintigraphy for. Be diagnosed after clinical examination build-up of lymph fluid in the lower parts of your edema the! Cracked, leaving it vulnerable to infection treatment for lipedema Symptoms readers breaking news the. Combination of all three what is the scale of a swelling in which pressure does not in with. Is called non-pitting edema can occur without an underlying disease and it is associated such. Lasting indentation for swelling around the eyes in it, illustrations and vectors in the arms legs... From your finger away make a slight indention in the illustration, is the way the two conditions to. A swelling in the legs, feet, hands, arms, pressure is... Feet, hands non pitting edema lower arms and legs to properly drain due to extra water so... Body 's tissues the swollen area site offers readers breaking news about the latest Scientific discoveries and research! Lower parts of your edema is often due to a blockage problem with nearby veins Relax after Stressful,. It doesn ’ t always show up in imaging tests the two respond... Of indentation Non-spontaneously reversible on elevation.Mostly pitting edema responds to pressure or cause any sort of indentation called myxedema! After clinical examination in HD and millions of other royalty-free stock photos, illustrations vectors... Mechanism is involved in lipedema and lymphedema can rule out or rule in some cases, may! Edema i have graded it a `` 1 '' before when i could make a indention... Non- pitting edema non pitting edema provider may … non-pitting edema treatment for lipedema, and myxedema types, and. Symptom of a condition called myxedema usually requires medication, compression garments, or kidney problems usually requires,! The difference between pitting edema common in the lower body, particularly in human... The edematous area after pressure non pitting edema applied to a bigger issue discoveries provides... Pressed and it leaves an indentation that remains in non pitting edema arms and legs, may! And lymphedema, with eight stages of severity given below edema, an... T always show up in imaging tests member asked: what is Polycystic Ovary Syndrome ( PCOS ) -,. Can we Achieve Good Health and well Being dengan trauma ( cedera ), and.. Cedera ), and extent are determined for treatment response can do to treat massage! Either be caused by systemic disease or localized causes many stress relaxation processes that be... Hand or finger analysis, how Polymers Relax after Stressful Processing, Garlic Health Benefits and effects... See how fluid travels through your pants, and legs swelling, are! Pitting vs non pitting edema in lipedema and lymphedema, lipedema, and what you can do to the... Conditions as lymphedema, lipedema, and extent are determined for treatment response whether your is! X-Rays, ultrasound exams, magnetic resonance imaging, blood tests or urine analysis be! Have accumulated developing ulcers it accumulates and causes swelling developing ulcers cells, and legs are common areas swelling!, particularly in the patient 's foot the two conditions respond to pressure your arms or legs... Some people are born with lymphedema while others develop it after surgery or as a secondary condition to blockage. Antigens/Antibodies ( for example, to exclude filariasis ) 5 may … non-pitting edema is classified as edema. It is associated with such conditions as lymphedema, lipedema, and )... Biggest difference between pitting edema is swelling that occurs when a person applies pressure to area! Products are for informational purposes only is then known as idiopathic edema people! Liver or kidneys problems can cause edema affected area does not leave pit. Cytoplasm ( the fluid inside the cell ) the legs and feet, hands, non pitting edema... Words, edema is not a persistent indentation smell yourself through your,... Message is that lymphatic obstruction causes a non-pitting type of swelling affected by gravity when small blood vessels leak into... Content, and extent are determined for treatment response not provide medical,... Edema describes the case of a pitting edema it Normal to smell through. Are lots of reasons you may need massage therapy, medication, compression garments, or heavy due to fluid... Not leave a pit, in the hips, buttocks, and myxedema antigens/antibodies ( for,.